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<p style="max-width: 100%; min-height: 1em; color: rgb(62, 62, 62); font-family: 微软雅黑; font-size: 16px; white-space: normal; text-align: justify; line-height: 1.75em; letter-spacing: 0.5px; box-sizing: border-box !important; word-wrap: break-word !important; background-color: rgb(255, 255, 255);"><img class="__bg_gif" data-ratio="0.10555555555555556" src="http://mmbiz.qpic.cn/mmbiz/M2H0aGBjWUTRia7nqkArYeKZUqEfdmpNibMPiaZk4gvlWk5v5lUKyXhjJP4CENKQeQt5HI8zwcTCWJOkicfWJiatdJQ/0?wx_fmt=gif" data-type="gif" data-w="720" style="line-height: 25.6px; box-sizing: border-box !important; word-wrap: break-word !important; visibility: visible !important; width: auto !important;" width="auto" /><span style="max-width: 100%; font-size: 15px; color: rgb(38, 38, 38); box-sizing: border-box !important; word-wrap: break-word !important;"></span></p><p>美国民众和政府越来越不愿意为高价的药物买单,这正在对全球药企的收入形成长期压力。</p><p><br /></p><section class="editor"><p style="text-align:center"><img data-s="300,640" data-type="jpeg" src="http://mmbiz.qpic.cn/mmbiz_jpg/dx3KibwtDhvdZo82RXicoTFLou2adMNgsibKKgM6zTFuiaLQuuFA1Ilp7pTY3dMSe67nU0puXVhDDjtIXUqkib7YMuQ/0?wx_fmt=jpeg" class="" data-ratio="0.5689655172413793" data-w="580" /></p></section><p><br /></p><p>据英国《金融时报》消息,医药市场研究机构EvaluatePharma6月20日宣布下调全球制药公司的收入预期,将未来五年(2017-2022年)全球药企的收入预期下调3900亿。</p><p style="text-align:center"><img data-s="300,640" data-type="png" src="http://mmbiz.qpic.cn/mmbiz_png/dx3KibwtDhvdZo82RXicoTFLou2adMNgsibrFKias2vkeS8JAn1oerdQQ4WH42qztAZRRy4SfhDF4I2tSr2p0Ee1Zg/0?wx_fmt=png" class="" data-ratio="0.696551724137931" data-w="580" /></p><section class="editor"><p style="text-align: center;"><br /></p></section><p><br /></p><p>这是EvaluatePharma十年来第一次下调药企收入预期。Evaluate预测部门负责人Antonio Iervolino称:“不论是已上市的药品,还是未来的新药,美国政府和民众都在密切关注药品的价格,我们认为这种关注短期内不会消失,现在制药企业已经开始承受压力。”</p><p>的确,近期包括安进的Repatha、赛诺菲的Praluent和诺华的Entresto在内的高价创新药品都在美国市场上面临销量不振的局面。制药巨头也已纷纷公开承诺降低药价,艾伯维、艾尔建、赛诺菲等都在名单之中。</p><p>不过,因为研发成本的上涨,也有企业在继续提高价格。美国制药公司辉瑞本月就提高了旗下90种药物的价格,平均涨幅达20%。Iervolino称,药物研发的成本正在不断上升,目前一款药物的十年研发期间耗费的成本已达到近40亿。在药价降低的背景下,药企的产品创新将会面临更大的压力。</p><p>近年来的几次药企恶性涨价事件使得反对药价上涨成为美国社会最重要的公众议题之一。</p><p><br /></p><p>2014年,图灵制药前CEO马丁?史克雷利(Martin Shkreli)将一款治疗艾滋病的药物从13.5美元一片提价到750美元一片。去年,制药公司迈兰旗下明星药品EpiPen被曝光七年涨价四倍多,CEO希瑟·布雷施(Heather Bresch)也因此受到美国国会调查。同一年,另一家制药公司Novum Pharma旗下的一款治疗痤疮的药膏在18个月内涨价了39倍,售价最后高达近一万美元一支。</p><p>买入专利到期、但几乎没有仿制药竞争的产品,然后大幅提价以使商业利益最大化,这已成为美国一些制药企业的商业模式,商业医保体系则为这些上涨费用买单。但是,药价提价过快必定导致商业保险的价格上涨和自费比例的提高,民众这时便会感受到药价上升的痛苦。</p><p><img data-s="300,640" data-type="jpeg" src="http://mmbiz.qpic.cn/mmbiz_jpg/dx3KibwtDhvdZo82RXicoTFLou2adMNgsibV4CDhToawFutyFJXGtWXKyU9BYKIRVLMicDPcwoVBAUfBcnUrWDKcAQ/0?wx_fmt=jpeg" class="" data-ratio="0.5689655172413793" data-w="580" /></p><p>除了民众的抵制外,美国政府也关注药价的上涨。就在上周,美联储主席耶伦点名指出,药价是造成美国通胀的部分原因。业界预期,美国总统特朗普也将在近期出台关于药价的行政法令,他面临的难题将是,要怎样在民众的支付能力和药企的研发动力之间取得平衡。</p><p style="max-width: 100%; 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