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<section data-role="paragraph" data-color="rgb(182, 228, 253)" data-custom="rgb(182, 228, 253)"><section><section><section><section powered-by="gulangu"><section><section><section><section powered-by="gulangu"><section><section><section><section powered-by="gulangu"><section><section><section><section powered-by="gulangu"><section><section><section><section><p><p><img src="image/20201014/86b79d371e9862b01189f0252a03b2cd_1.png" /></p></p></section><section><section><span><strong></strong></span></section><p><span>医疗器械媒体报道先锋</span></p><p><span>分享专业医疗器械知识</span></p></section><section><section><section><span>关注</span></section></section></section></section></section></section></section></section></section></section></section></section></section></section></section></section></section></section></section></section></section></section></section><p><br /></p><p><span>在我们的印象里，3D打印技术往往与笨重的3D打印机挂钩，尤其是医学3D打印机，需要极致精准，因此一般都由高精度的设备组成，而科学家总是能挑战人们的认知极限，下面我们来了解两款手持式的医学3D打印设备。</span><br /></p><p><span><br /></span></p><p><p><img src="image/20201014/3eea98dad5e3e6dc9f48304343fb5d77_2.png" /></p></p><p><br /></p><p><strong><span>手持式3D打印骨肌修复设备</span></strong><br /></p><p><br /></p><p><span>美国康涅狄格大学的科学家开发了一款能够完成骨肌修复的手持式3D打印机。</span></p><p><br /></p><p><p><img src="image/20201014/8acc647b1a93c0db77844ce80d817ef4_3.jpg" /></p></p><p><br /></p><p><span>简而言之，它们是植入体内的三维生物相容性材料，其微观结构类似于周围组织。随着时间的流逝，来自该组织的细胞迁移到支架中，使其聚居居并繁殖。最终，它们完全替代了材料，形成了肌肉、骨骼、软骨或其他组织。</span></p><p><br /></p><p><span>也就是说，预先生产这种生物支架，然后将其植入肌肉是非常具有挑战性的。考虑到这一点，康涅狄格大学的科学家开发了一款手持式3D打印机原型来完成这项工作。</span></p><p><br /></p><p><p><img src="image/20201014/30aa37e6d7504641b74bc6be8c605330_4.gif" /></p></p><p><br /></p><p><span>首先，科学家将基于明胶的水凝胶直接沉积到肌肉内不需要的间隙中。集成的紫外线可使凝胶固化成由微小的类肌肉纤维组成的生物支架，该生物支架易于粘附在相邻的肌肉组织上，无需缝合。肌肉细胞然后进入支架。在实验室测试中，该设备被证明可有效治疗小鼠的体积性肌肉损伤。</span></p><p><br /></p><p><span>由Ali Tamayol博士领导的有关该研究的论文最近发表在《ACS Applied Bio Materials》杂志上。</span></p><p><span><br /></span></p><p><strong><span>3D打印笔绘制人类干细胞<br /></span></strong></p><p><span><br /></span></p><p><span>2016年，来自澳大利亚的研究团队在《Biofabrication》杂志上刊登了一篇通过3D打印笔在自由模式下成功绘制出具有较高生存率的人类干细胞的文章。</span><span>研究者开发的这种新型设备可以帮助外科医生在手术期间进行个性化的软骨移植。</span></p><p><span><br /></span></p><p><p><img src="image/20201014/505f9731f410f378547af498a778cf3c_5.jpg" /></p></p><p><br /><span></span></p><p><span>研究者指出，利用水凝胶式的“生物墨水”来携带并且支持人类干细胞生长，并且利用较低的光源来凝固“生物墨水”这种打印笔运输的干细胞的存活率就会超过97%。</span><span>而这种新型的3D打印笔同时也为组织工程学研究带来极大帮助，比如其可以逐层打印出细胞，用来构建可供移植的人工组织。</span></p><p><span><br /></span></p><p><span>但在某些情况下，比如进行软骨修复的过程中，植入物的精确几何学特性或许就不能够被精确应用于外科手术中，这就使得进行人工软骨组织移植物的前准备工作变得复杂而且困难；</span><span>新型打印笔的作用就好像外科医生的手一样，可以将定做好的支架或移植物准确填入患者机体缺失的部位。</span><span>研究者Choong教授说道，这种新型设备的开发是科学家和临床医生共同努力的成果，对于改善研究以及患者的治疗将带来空前的改变。</span></p><p><span><br /></span></p><p><span>这种打印笔比较轻便小巧、具有人体工程学特性及可消毒特性，同时还配备有较低功率的光源及固化剂；</span><span>研究者认为这种新型设备后期将可以更好地帮助科学家们“绘制打印”出人类干细胞以供临床研究是治疗之用。</span></p><p><span><br /></span><br /></p><p><br /></p><section data-role="outer" label="Powered by 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发表于 2020-10-14 12:50:37