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<section data-role="paragraph" data-color="rgb(182, 228, 253)" data-custom="rgb(182, 228, 253)"><section><section><section><section powered-by="gulangu"><section><section><section><section powered-by="gulangu"><section><section><section><section powered-by="gulangu"><section><section><section><section powered-by="gulangu"><section><section><section><section><p><p><img src="image/20201014/86b79d371e9862b01189f0252a03b2cd_1.png" /></p></p></section><section><section><span><strong></strong></span></section><p><span>医疗器械媒体报道先锋</span></p><p><span>分享专业医疗器械知识</span></p></section><section><section><section><span>关注</span></section></section></section></section></section></section></section></section></section></section></section></section></section></section></section></section></section></section></section></section></section></section></section><p><br /></p><p><span>疫情发生以来被视作“潜在抗疫神药”的瑞德西韦，居然是无效的？</span></p><p><span><br /></span></p><p><span>4月24日凌晨，英国《金融时报》报道，此前世卫组织意外泄露的报告称，被称为“人民的希望”的抗疫潜在有效药物瑞德西韦，在其治疗新冠病毒的首个随机临床试验中失败。</span></p><p><br /></p><p><span>据报道，世界卫生组织(World Health Organization)不小心公布的文件草稿称，实验性抗病毒药物瑞德西韦在治疗COVID-19的首个随机临床试验中失败，这篇报道随后被删除。</span></p><p><br /></p><p><span>根据健康新闻网站STAT发布的截图，实验总结称，与对照组相比，瑞德西韦与"临床改善时间上的差异无关"。</span></p><p><br /><span>研究发现一个月后，服用瑞德西韦的患者中有13.9%死亡，而对照组中只有12.8%死亡。</span></p><p><br /></p><p><p><img src="image/20201014/0a2ec65bfebcca689bdb88a1be7f6758_2.jpg" /></p></p><p><br /></p><p><span><strong><span>但瑞德西韦真的对抗疫无效？</span></strong></span></p><p><span><br /></span></p><p><span>目前给出这结论，显然操之过急了。研发公司吉利德就公开发布消息称，WHO的该文件草案有“对研究的不当描述”，而且该药的研究结果“没有定论”。</span></p><p><span><br /></span></p><p><span>而世卫组织也表示，这份草稿在无意中被发布到网站上，在意识到之后已经立马撤下。该组织强调，瑞德西韦研究草案正在接受同行的审查，正在等待最终版本。</span></p><p><span><br /></span></p><p><span><strong><span>瑞德西韦在中国试验中断是因疫情好转</span></strong></span></p><p><span><br /></span></p><p><span>尽管吉利德公司的声明有自辩成分，但其描述的情况也是实情。</span></p><p><span><br /></span></p><p><span>吉利德公司起初预计，将在四月底获得瑞德西韦针对重症患者研究的初步数据。但之后其临床试验研究确实因“客观原因”中断了。</span></p><p><span><br /></span></p><p><span><strong><span>什么客观原因？</span></strong></span></p><p><span><br /></span></p><p><span>那就是：中国疫情已经得到良好控制，当前没有符合条件的患者入组，无论是成人重症试验还是轻症和中症病人临床试验，都因此不得不终止——病人数量不足，自然无法进行后续的有效数量的随机双盲对照研究。</span></p><p><span><br /></span></p><p><span>也就是说，试验难以为继，不等于瑞德西韦就无效，只能说试验因为缺少病人而难以做下去。</span></p><p><span><br /></span></p><p><span>临床试验做不下去，当然不可能得出结果，无论是积极的还是消极的结果。没有结果，当然也难以判断瑞德西韦的疗效。因此，现在既不能肯定瑞德西韦有效，也不能确认其无效。</span></p><p><br /></p><p><span><strong><span>厂家怎么说？</span></strong></span></p><p><br /></p><p><span>吉利德的一位发言人告诉法新社："我们认为这篇文章包含了对研究的不恰当描述。"他说，由于注册人数少，研究被提前终止了，因此,在统计学上没有意义。</span></p><p><br /><span>他说："尽管数据的趋势表明对瑞德西韦有潜在的好处，特别是在疾病早期治疗的患者中，但是研究结果仍然是不确定的。"这项研究并不代表对这个问题的最终结论，还有几项处于后期阶段的大规模试验应该很快会提供一个更清晰的结论。</span></p><p><br /></p><p><span>就此看，瑞德西韦是否有效，要取决于未来更多的试验，而不是现在。</span></p><p><br /></p><section data-role="outer" label="Powered by gulangu"><section data-role="paragraph" 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发表于 2020-10-14 12:27:07