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<section data-color="rgb(182, 228, 253)" data-custom="rgb(182, 228, 253)"><section><section><section><section><section><section><section><section><section><section><section><section><section><section><section><section><section><section><section><section><section data-color="rgb(182, 228, 253)" data-custom="rgb(182, 228, 253)"><section><section><section><section><section><section><section><section><section><section><section><section><section><section><section><section><section><section><section><section><p><p><img src="image/20201014/86b79d371e9862b01189f0252a03b2cd_1.jpg" /></p></p></section><section><section><span><strong></strong></span></section><p><span>医疗器械媒体报道先锋</span></p><p><span>分享专业医疗器械知识</span></p></section><section><section><section><span>关注</span></section></section></section></section></section></section></section></section></section></section></section></section></section></section></section></section></section></section></section></section></section></section></section><section data-role="paragraph"><section data-tplid="89781" data-tools="gulangu"><section data-tools="gulangu" data-id="95298"><section><section><section><span></span></section><section powered-by="gulangu"><section><section powered-by="gulangu"><section><section powered-by="gulangu"><p><br /></p><section><span>核磁共振(NMR)技术凭借其高空间分辨率，宽时间响应尺度和非侵入检测等特点，在化学分析和医疗诊断中发挥着重要的作用。但是原子核的低极化使现阶段NMR技术的灵敏度较低。超极化技术是一类可以有效提高NMR灵敏度的方法。其通过物理或化学过程把原子核自旋态推向一个偏离热力学平衡的状态，使NMR信号强度得到几个数量级的提升，极大地改善了灵敏度。<strong>与质子MRI不同，超极化气体肺部MRI可以肺部气体空间或肺部组织内的自旋成像，为肺部MRI增加了实质性的价值和诊断潜力</strong>。</span></section><section><br /></section><section data-support="96编辑器" data-style-id="22631"><section><section><p><strong>01</strong></p></section><section><section data-brushtype="text" hm_fix="289:275"><strong><span>MRI信号增强10万倍</span></strong></section></section></section></section><section><br /></section><section><span>近日，美国Polarean Imaging公司的超极化气体磁共振，正在进行一项研究，用来对肺部进行成像，旨在帮助诊断呼吸系统疾病。</span><br /><br /></section><section><p><img src="image/20201014/f88fb658f24affb71065aaff2dcf069b_2.jpg" /></p></section><h4><trans oldtip="Polarean 9600 " newtip="波林9600"><span>Polarean 9600 </span></trans><trans oldtip="He Hyperpolarizer" newtip="超偏振器"><span>He Hyperpolarizer</span></trans><trans oldtip="He Hyperpolarizer" newtip="超偏振器"></trans><trans oldtip="He Hyperpolarizer" newtip="超偏振器"></trans></h4><section><br /></section><section><span>Polarean Imaging公司的Polarean 9600超极化偏振器通常安装在磁共振成像/核磁共振装置附近，并将非极化氦（3He）和氮（N2）的定制混合物处理成一剂或多剂高纯度、超级化的氙气和氦气，患者吸入后进行10-20秒的磁共振扫描，据公司的数据表明，这样可使得<strong>MRI信号增强10万倍</strong>。</span></section><section><br /></section><section><span>这种增强的信号可能使无创性研究肺部结构成为可能，这是单靠核磁共振是不可能的。例如，有可能识别出肺通气不良的区域，并量化肺内通风空间的体积。实际上，这样的测量可以让临床医生想象肺功能，而不仅仅是肺结构。</span></section><section><br /></section><section><span>此外，Polarean 9600氦超极化系统可由经过适当培训的人员在现场操作。偏振度范围为25-55%，取决于处理速度和光学元件质量。1升并将非极化氦可以在4-12小时内完成超级化。该系统作为一级激光器运行，因此在正常运行期间不需要激光防护眼镜。</span></section><section><br /></section><section data-support="96编辑器" data-style-id="22631"><section><section><p><strong>02</strong></p></section><section><section data-brushtype="text" hm_fix="289:275"><strong><span>Polarean Imaging拥有GE血统</span></strong></section></section></section></section><section><br /></section><section><span>据悉，Polarean Imaging公司成立于2012年1月，总部位于美国北卡罗莱纳州Durham，拥有GE Healthcare在超极化气体MRI领域的全部资产。GE医疗在超级化领域的研究颇有时日，GE旗下公司Research Circle Technology于2011年推出过一款SPINlab超极化系统，该系统设计用于研究中的细胞水平代谢的快速可视化。</span></section><section><span><br /></span></section><section><p><img src="image/20201014/94289dc6d61341b347d4b53cfdbfc4cb_3.jpg" /></p></section><section><span>SPINlab</span></section><section><br /></section><section><span>以前，具有类似功能的系统需要洁净室，大量氦气和大量训练有素的人员进行操作。SPINlab系统集成了专用的流体路径，质量控制以及同时对多个样品进行超极化的能力。</span></section><section><span><br /></span></section><section><span>目前Polarean Imaging公司正在寻求Polarean 9600的临床应用。</span></section><section data-role="paragraph"><section data-role="paragraph"><section data-tplid="89781" data-tools="gulangu"><section><section><section><section><br /></section><section data-support="96编辑器" data-style-id="22631"><section><section><p><strong>03</strong></p></section><section><section data-brushtype="text" hm_fix="289:275"><strong><span>国内的研究</span></strong></section></section></section></section><section><br /></section><section><span>2010年，周欣团队开始开展超极化气体肺部MRI成像技术研究，并最终选择氙—129作为成像所需的气体。据了解，超极化氙—129良好的脂溶性和化学位移敏感性，使其在肺部气血交换功能探测上具有独特的优势，不仅能反映肺部的形态学信息，也可以提供肺部的生理功能信息，能够只使用一种手段就得到扩散、弥散、灌注等多方面信息。</span></section><section><span><br /></span></section><section><span>“我们这项研究不仅获得肺部的结构信息，还将对肺部气体交换功能进行可视化研究，从而展开人体肺部重大疾病的诊断前研究。”周欣说，“主要原理是：先利用激光技术增强电子自旋信号，然后将电子信号转移增强惰性气体的磁共振信号，进而对肺部气体进行成像。”</span></section><section><br /></section><section><span>由于检测时患者要吸入氙气，为了让他们能提早适应，所以在检测前有两次吸气练习。一次练习在进入扫描间之前进行，另外一次则在正式检测前，练习用的气体是氮气。患者需穿戴线圈后</span><span>平躺在检测床上，</span><span>将提前制备好的一袋氙—129慢慢吸入，屏住呼吸6秒钟，可完成检查，</span><span>过程很快，患者不会有任何不适感。</span><span>超极化氙—129肺部磁共振成像技术突破了传统磁共振成像不能对肺部空腔成像的限制，成功“点亮”肺部，为多种疾病的诊断及分期带来可能。</span></section><p><br /></p><p><span>来源：智械猎新、Polarean</span></p><p><br 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发表于 2020-10-14 10:34:30