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近200年来首次:中国医疗器械登上《柳叶刀》

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发表于 2020-10-19 22:49:39 | 显示全部楼层 |阅读模式

                    

                    

                    
                    
                    <p style="max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quotingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;"><img data-type="gif" class="__bg_gif " data-ratio="0.10555555555555556" data-w="720" src="http://mmbiz.qpic.cn/mmbiz/M2H0aGBjWUTRia7nqkArYeKZUqEfdmpNibMPiaZk4gvlWk5v5lUKyXhjJP4CENKQeQt5HI8zwcTCWJOkicfWJiatdJQ/640?wx_fmt=gif" style="box-sizing: border-box !important;word-wrap: break-word !important;visibility: visible !important;width: auto !important;"  /></p><p style="max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quotingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;"><span style="max-width: 100%;font-size: 12px;color: rgb(136, 136, 136);box-sizing: border-box !important;word-wrap: break-word !important;">来源:扬子晚报</span></p><p style="max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quotingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;"><span style="max-width: 100%;font-size: 12px;color: rgb(136, 136, 136);box-sizing: border-box !important;word-wrap: break-word !important;"><br  /></span></p><p style="margin-right: 5px;margin-left: 5px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: 微软雅黑;font-size: 16px;text-align: justify;white-space: normal;background-color: rgb(255, 255, 255);line-height: 1.75em;letter-spacing: 0.5px;box-sizing: border-box !important;word-wrap: break-word !important;"><span style="max-width: 100%;font-size: 15px;color: rgb(63, 63, 63);box-sizing: border-box !important;word-wrap: break-word !important;"></span></p><p style="line-height: 2em;margin-bottom: 15px;"><span style="font-size: 14px;color: rgb(0, 0, 0);">伦敦时间9月3日23时30分(北京时间9月4日6时30分),对全球医学界权威学术刊物《柳叶刀》和中国医疗器械行业而言,都是一个“史无前例”的日子。</span></p><p style="line-height: 2em;margin-bottom: 15px;text-align: center;"><img class="" data-copyright="0" data-ratio="0.705" data-s="300,640" src="http://mmbiz.qpic.cn/mmbiz_jpg/dx3KibwtDhve2Ujs6Df0WCEVyj7yjLVayhHm5IGm2nAytzPAoguSUyM3WKLdfvEWcYe33dGbJhNjzvIqzDaE4Hg/640?wx_fmt=jpeg" data-type="jpeg" data-w="400" style=""  /></p><p style="line-height: 2em;margin-bottom: 15px;text-align: center;"><span style="font-size: 14px;color: rgb(0, 0, 0);">“火鹰支架”登上《柳叶刀》。</span></p><p style="line-height: 2em;margin-bottom: 15px;"><span style="font-size: 14px;color: rgb(0, 0, 0);">该杂志全文刊登了上海微创医疗器械(集团)有限公司(以下简称“微创”)自主研发的火鹰支架在欧洲大规模临床试验的研究结果,称该研究破解了困扰世界心血管介入领域10多年的重大难题,这是《柳叶刀》创刊近200年来首次出现中国医疗器械的身影。</span></p><p style="line-height: 2em;margin-bottom: 15px;text-align: center;"><img class="" data-copyright="0" data-ratio="0.72" data-s="300,640" src="http://mmbiz.qpic.cn/mmbiz_jpg/dx3KibwtDhve2Ujs6Df0WCEVyj7yjLVayuib3EPMNgIX1x4lD6CdTrzBygB5YYsxFgSZ50efekAdLcrRVZ1bLbfA/640?wx_fmt=jpeg" data-type="jpeg" data-w="400" style=""  /></p><p style="line-height: 2em;margin-bottom: 15px;"><span style="color: rgb(0, 0, 0);"><strong><span style="color: rgb(0, 0, 0);font-size: 14px;">叫板“国际金标准”</span></strong></span></p><p style="line-height: 2em;margin-bottom: 15px;"><span style="font-size: 14px;color: rgb(0, 0, 0);">作为影响因子最高的SCI刊物之一,《柳叶刀》对刊载文章的审核极为苛刻,每篇文章都需多名同行专家多次严格评审,确保学术水准和客观真实,从投稿到刊登通常耗时数月,长达一两年的也比比皆是。然而,对来自中国医疗器械领域的这张“生面孔”,《柳叶刀》却一改“漫长”作风,从收稿到刊登仅用了不到一个月,且5位评审专家一致投“同意票”,给予积极评价,堪称学术界佳话。</span></p><p style="line-height: 2em;margin-bottom: 15px;"><span style="color: rgb(0, 0, 0);"><strong><span style="color: rgb(0, 0, 0);font-size: 14px;">“宇航级”技术</span></strong></span></p><p style="line-height: 2em;margin-bottom: 15px;"><span style="color: rgb(0, 0, 0);"><strong><span style="color: rgb(0, 0, 0);font-size: 14px;">15年研发出微槽包裹药物</span></strong></span></p><p style="line-height: 2em;margin-bottom: 15px;"><span style="font-size: 14px;color: rgb(0, 0, 0);">在心脏支架领域,药物的承载是一个困扰专业人士10多年的难题。目前,国内外传统主流心脏支架都是在金属支架表面涂上细胞抑制剂,才能使血管持续通畅,降低血管再狭窄的发生率。</span></p><p style="line-height: 2em;margin-bottom: 15px;"><span style="font-size: 14px;color: rgb(0, 0, 0);">但这样做仍有不足:首先,药物支架表面的涂层在血管装载过程中如果遇到像钙化等复杂病变时,容易脱落、破损,会影响治疗效果,更可能加剧新的血栓的形成。</span></p><p style="line-height: 2em;margin-bottom: 15px;"><span style="font-size: 14px;color: rgb(0, 0, 0);">其次,药物的承载量难以控制,装少了容易在达到病变区之前过早损耗,装多了则容易过犹不及,对人体造成负担。</span></p><p style="line-height: 2em;margin-bottom: 15px;"><span style="font-size: 14px;color: rgb(0, 0, 0);">怎样把药物完美地“保存”在支架上?经过反复设计和比较,火鹰研发团队历时15年,选择并达成了技术上最难实现的一种方案——微槽包裹药物,即在金属支架表面用激光刻槽,再把药物灌入槽内。</span></p><p style="line-height: 2em;margin-bottom: 15px;"><span style="font-size: 14px;color: rgb(0, 0, 0);">和传统技术的区别在于,刻槽可防止涂层在输送过程中脱落,药物不会流失,且药物抵达血管病变区后,能通过固定的槽位精准释放,大幅提高了有效性,也避免了浪费。</span></p><p style="line-height: 2em;margin-bottom: 15px;"><span style="color: rgb(0, 0, 0);"><strong><span style="color: rgb(0, 0, 0);font-size: 14px;">在头发丝上“挖”出600个凹槽</span></strong></span></p><p style="line-height: 2em;margin-bottom: 15px;"><span style="font-size: 14px;color: rgb(0, 0, 0);">此外,由于精准释放而非漫无目的“扫射”,可以避免在无效面上载药,从而避免过多药物对表皮细胞的抑制,使支架尽快被表皮覆盖,这让药物支架使用者术后服用双重抗血小板药物的时间缩短。</span></p><p style="line-height: 2em;margin-bottom: 15px;"><span style="font-size: 14px;color: rgb(0, 0, 0);">据悉,目前传统药物支架的使用者需长时间服用该类药物,以避免血栓、血小板难以凝结等并发症,这些药物有一定的副作用,且价格昂贵,目前国内的双抗药物中,较便宜的品种每年也需要花费近万元。支架技术的改良,为患者普遍节省了一大笔术后费用。</span></p><p style="line-height: 2em;margin-bottom: 15px;"><span style="font-size: 14px;color: rgb(0, 0, 0);">由于空间极其有限,在金属支架表面用激光刻槽的难度甚至比“发雕”还要高出不少——要在细如头发丝却极其坚硬的钴铬合金上均匀“挖”出近600个凹槽。为将药物精准地注入这些微型凹槽,微创自主研发了10多台独一无二的药物涂层喷涂设备,可将误差控制在微米级别,药物涂层的面积仅占金属覆盖面积的20%。对于这项技术,火鹰研发团队的技术人员笑称这是医疗器械领域的“宇航飞船船舱对接”,因为采用的正是最先进的航天级目标智能捕捉与定位技术。</span></p><p style="line-height: 2em;margin-bottom: 15px;"><span style="color: rgb(0, 0, 0);"><strong><span style="color: rgb(0, 0, 0);font-size: 14px;">全球8000家医院都在用它</span></strong></span></p><p style="line-height: 2em;margin-bottom: 15px;"><span style="font-size: 14px;color: rgb(0, 0, 0);">随着火鹰支架在欧洲十国一炮打响,目前其已在全球36个国家和地区上市或完成注册,而以“微创”为代表的中国医疗器械品牌正被越来越多的人认可。</span></p><p style="line-height: 2em;margin-bottom: 15px;"><span style="font-size: 14px;color: rgb(0, 0, 0);">最新数据显示,微创已上市产品约300个,覆盖心血管介入及结构性心脏病医疗、心脏节律管理及电生理医疗、骨科植入与修复、大动脉及外周血管介入等10个业务领域,产品已进入全球逾8000家医院,覆盖亚太、欧洲和美洲等主要地区。</span></p><p style="line-height: 2em;margin-bottom: 15px;"><span style="font-size: 14px;color: rgb(0, 0, 0);">目前,在世界范围内,平均每12秒就有一个微创的产品被用于救治患者生命或改善患者的生活品质或用于帮助其催生新的生命。截至2017年底,微创生产的包括火鹰支架在内的约450万个冠脉产品已救治了全球约350万名患者,产品植入成功率超过99.995%。</span></p><p style="line-height: 2em;margin-bottom: 15px;"><span style="font-size: 14px;color: rgb(0, 0, 0);">而国家心血管病中心发布的《中国心血管病报告2017》显示,我国心血管病现患人数为2.9亿,每10秒就有1人死于心血管病,且患病群体呈年轻化趋势,35到44岁的男性患者在过去15年增加了111%。心血管病死亡占居民疾病死亡构成的40%以上并居首位,心血管病已成为国家重大的公共卫生问题。</span></p><p style="line-height: 2em;margin-bottom: 15px;"><span style="font-size: 14px;color: rgb(0, 0, 0);">该研究表明,火鹰支架的使用者服用双重抗血小板药物的时间预期可以从长期治疗缩短至1个月,可为患者每人每年节省近万元,如果服用其他新型抗血小板凝聚药物则节省更多,可为国家医保每年节省支出近60亿元。</span></p><p 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style="max-width: 100%;font-size: 14px;line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;">邮编:510507</span></p><p style="margin-bottom: 5px;max-width: 100%;min-height: 1em;font-size: 12px;letter-spacing: 0.544px;text-align: justify;text-indent: 0em;white-space: normal;background-color: rgb(255, 255, 255);color: rgb(62, 62, 62);font-family: Arial, Verdana, sans-serif;line-height: 2em;box-sizing: border-box !important;word-wrap: break-word !important;"><span style="max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;">电话:(+86)020-8722 8723 &nbsp; &nbsp;8764 5360 &nbsp; &nbsp;</span></p><p style="margin-bottom: 5px;max-width: 100%;min-height: 1em;font-size: 12px;letter-spacing: 0.544px;text-align: justify;text-indent: 0em;white-space: normal;background-color: rgb(255, 255, 255);color: rgb(62, 62, 62);font-family: Arial, Verdana, sans-serif;line-height: 2em;box-sizing: border-box !important;word-wrap: break-word !important;"><span style="max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;">传真:020-8722 8623</span></p><p style="margin-bottom: 5px;max-width: 100%;min-height: 1em;font-size: 12px;letter-spacing: 0.544px;text-align: justify;text-indent: 0em;white-space: normal;background-color: rgb(255, 255, 255);color: rgb(62, 62, 62);font-family: Arial, Verdana, sans-serif;line-height: 2em;box-sizing: border-box !important;word-wrap: break-word !important;"><span style="max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;">全国统一免费服务热线:400-020-6788</span></p><p style="margin-bottom: 5px;max-width: 100%;min-height: 1em;font-size: 12px;letter-spacing: 0.544px;text-align: justify;text-indent: 0em;white-space: normal;background-color: rgb(255, 255, 255);color: rgb(62, 62, 62);font-family: Arial, Verdana, sans-serif;line-height: 2em;box-sizing: border-box !important;word-wrap: break-word !important;"><span style="max-width: 100%;line-height: 24.381px;box-sizing: border-box !important;word-wrap: break-word !important;">公司官网:http://www.parts-ultrasound.com/</span><span style="max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;"></span></p><p style="margin-bottom: 5px;max-width: 100%;min-height: 1em;font-size: 16px;letter-spacing: 0.544px;text-align: justify;white-space: normal;background-color: rgb(255, 255, 255);color: rgb(62, 62, 62);font-family: 微软雅黑;line-height: 2em;box-sizing: border-box !important;word-wrap: break-word !important;"><span style="max-width: 100%;line-height: 1.75em;text-indent: 0em;font-size: 14px;font-family: Arial, Verdana, sans-serif;box-sizing: border-box !important;word-wrap: break-word !important;">微信公众帐号:</span></p><p style="max-width: 100%;min-height: 1em;font-size: 16px;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);color: rgb(62, 62, 62);line-height: 25.6px;text-align: center;font-family: 微软雅黑;box-sizing: border-box !important;word-wrap: break-word !important;"><img class="" data-ratio="1" data-s="300,640" data-type="jpeg" data-w="258" width="auto" src="http://mmbiz.qpic.cn/mmbiz_jpg/dx3KibwtDhvfh2wVX4NftfnfjcZWIKK6EQDWtTTsYwjfQBnsqkThAZP5OlDmg5S3g22gSqMWhAxr2O4MydSJHnQ/640?wx_fmt=jpeg" style="float: left;box-sizing: border-box !important;word-wrap: break-word !important;visibility: visible !important;width: auto !important;"  /></p><p style="margin-bottom: 5px;max-width: 100%;min-height: 1em;font-size: 12px;letter-spacing: 0.544px;text-align: justify;text-indent: 0em;white-space: normal;background-color: rgb(255, 255, 255);color: rgb(62, 62, 62);font-family: Arial, Verdana, sans-serif;line-height: 2em;box-sizing: border-box !important;word-wrap: break-word !important;"><span style="max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;">维修咨询:QQ: &nbsp;712638 404</span><br style="max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;"  /></p><p style="margin-bottom: 5px;max-width: 100%;min-height: 1em;font-size: 12px;letter-spacing: 0.544px;text-align: justify;text-indent: 0em;white-space: normal;background-color: rgb(255, 255, 255);color: rgb(62, 62, 62);font-family: Arial, Verdana, sans-serif;line-height: 2em;box-sizing: border-box !important;word-wrap: break-word !important;"><span style="max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;">设备咨询: &nbsp; QQ: &nbsp;712638 405</span></p><p style="margin-bottom: 5px;max-width: 100%;min-height: 1em;font-size: 16px;letter-spacing: 0.544px;text-align: justify;white-space: normal;background-color: rgb(255, 255, 255);color: rgb(62, 62, 62);font-family: 微软雅黑;line-height: 2em;box-sizing: border-box !important;word-wrap: break-word !important;"><span style="max-width: 100%;font-size: 14px;font-family: Arial, Verdana, sans-serif;line-height: 1.75em;text-indent: 0em;box-sizing: border-box !important;word-wrap: break-word !important;">软件咨询:QQ: 712638 406</span><br style="max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;"  /></p><p style="margin-bottom: 5px;max-width: 100%;min-height: 1em;font-size: 12px;letter-spacing: 0.544px;text-align: justify;text-indent: 0em;white-space: normal;background-color: rgb(255, 255, 255);color: rgb(62, 62, 62);font-family: Arial, Verdana, sans-serif;line-height: 2em;box-sizing: border-box !important;word-wrap: break-word !important;"><span style="max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;">配件咨询:QQ: &nbsp; 712638 407</span></p><p style="margin-bottom: 5px;max-width: 100%;min-height: 1em;font-size: 12px;letter-spacing: 0.544px;text-align: justify;text-indent: 0em;white-space: normal;background-color: rgb(255, 255, 255);color: rgb(62, 62, 62);font-family: Arial, Verdana, sans-serif;line-height: 2em;box-sizing: border-box !important;word-wrap: break-word !important;"><span style="max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;">交流Q群:1106 11074</span></p><p style="margin-bottom: 5px;max-width: 100%;min-height: 1em;font-size: 12px;letter-spacing: 0.544px;text-align: justify;text-indent: 0em;white-space: normal;background-color: rgb(255, 255, 255);color: rgb(62, 62, 62);font-family: Arial, Verdana, sans-serif;line-height: 2em;box-sizing: border-box !important;word-wrap: break-word !important;"><span style="max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;">阿里店铺网址:https://renchengyiliao.1688.com</span></p><p style="margin-bottom: 5px;max-width: 100%;min-height: 1em;font-size: 12px;letter-spacing: 0.544px;text-align: justify;text-indent: 0em;white-space: normal;background-color: rgb(255, 255, 255);color: rgb(62, 62, 62);font-family: Arial, Verdana, sans-serif;line-height: 2em;box-sizing: border-box !important;word-wrap: break-word !important;"><span style="max-width: 100%;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;">电子邮箱:sales@parts-ultrasound.com</span></p>
               
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